Swimming Improves Memory Function and Decreases N-Methyl-D-Aspartate in Ageing Rats

A single Memory impairment substantially reduces the quality of life in elderly. It is associated with thealteration neurotrophic (NT) factors, such as brain-derived factor (BDNF) and glutamatereceptor N-methyl-D-aspartate (NMDA). Exercise often used to reduce cognitive impairment. Previousstudies show that benefits aerobic exercises on impairments are correlated increasing BDNFand preventing production NMDA. However, some results remain controversial. Thus, associationbetween exercise was addressed by examining increases BDNF reduction NMDAin ageing rats. The study a randomized, post-test-only controlled group 30 male one-year-old ageingRattus norvegicus divided into three groups, namely, K0 (control) K1 K2 (aerobic swimmingexercise). animals differed frequency exercise, which four sessions perweek, respectively. assessed using Y-maze performance. NMDA were analyzedusing enzyme-linked immunosorbent assays. significant improvement memory function reductionin level observed rats (p = 0.001; p 0.041). No impact onthe levels 0.387). Swimming may boost reducing levelbut not BDNF. promising method for or delaying loss indegenerative brain diseases. Further investigation needed fully understand underlying mechanisms.